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Pozzi V, Mazzotta M, Muzio LL, Sartini D, Santarelli A, Renzi E, Rocchetti R, Tomasetti M, Ciavarella D, Emanuelli M (2011) Inhibiting proliferation in KB cancer cells by RNA interference-mediated knockdown of nicotinamide N-methyltransferase expression

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doi: 10.1016/j.neuint.2023.105604 15

Although each model differs in terms of CAG repeat length and transgene expression levels, and thus in the severity of the resulting HD phenotype, they were instrumental in demonstrating a fundamental feature of the disease, namely that severe neuronal dysfunction precedes degeneration and it is probably the primary cause of many HD symptoms 8,9