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[275] acknowledge that the underpinning of reduction in mutation rate in the Amish remains to be fully determined [275], the potential role played by the environment, particularly lifestyle factors, in shaping the human genome and susceptibility to diseases, such as cancer, deserves special attention

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Clinicians should recognize that different choices will be appropriate for different patients and that decisions must be consistent with each patients values and preferences.* * Knowledge translation tools are available on the task force website, at www.canadiantaskforce.ca, to facilitate decisions that are evidence informed and aligned with a persons priorities

Vaping is the process of heating an e-liquid to produce a vapour, which is then inhaled