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[Abstract]2019 Dec 17;29(12):3847-3858.e5

154 In addition, elevated levels of serum Cu have been correlated with both tumor stage and disease progression in patients with colorectal, lung, and breast cancer

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Here we dissect the etiology and pathology at specific stages: (i) triggering, (ii) maturation, (iii) targeting, and (iv) fulminant stage, concomitant with hyperplastic synovium, cartilage damage, bone erosion, and systemic consequences