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It has higher incidence in Scandinavian populations, shares risk factors with Parkinsons disease and Alzheimers diseases and was associated with mutations in the lysyl-oxidase-like 1 (LOXL1) gene, and mutations in loci encoding CACNA1A, TMEM136, SEMA6A and other genes

In the second step, the GS leads the reaction to bond formation cysteinyl-COOH of -GC and -NH 2 group of Gly, subsequently, the GSH is synthesized from -GGC (Figure 1)

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