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In prophase animal models, various pharmacological sEHIs, such as AUDA, AUDA-BE, t-AUCB, TPPU, and 1-adamantan-1-yl-3-urea (AEPU), showed that they are able to effectively lower hypertension, 476 alleviate multi-organ inflammation 477,478 and neuropathic pain, 413,479 inhibit cardiac hypertrophy, 480 detrimental cardiac remodelings and HF, 176 as well as to attenuate hepatocellular necrosis and hepatic fibrosis 481 and renal interstitial fibrosis and inflammation

FIGURE 9 Publishers Note All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Pediatrics 134 , e547e561 (2014)

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