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49 Cumulatively, these findings suggest supplementation with homocysteine-lowering B vitamins may confer benefits even among individuals whose homocysteine does not exceed normal lab reference ranges

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Further confirmation of fumarate as an oncometabolite was verified by experimental data showing that tumor cells lost their ability to invade and migrate when the function of fumarate hydratase was restored by an external expression vector 131

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doi: 10.1038/s41591-020-01225-1

This type of TN often appears without any other neurological deficits and is considered idiopathic apart from the vascular compression