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Among these approaches, the first-generation D+Q combination has accumulated the most experimental data regarding safety and efficacy, and CNS bioavailability (95-99)

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From animal poisons and venoms to medicines: Achievements, challenges and perspectives in drug discovery

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Necroptosis is characterized by the excessive accumulation of the products of oxidative stress, such as lipid hydroperoxides [218], end products of glycation [219], and increased activity of bioenergetic pathways, including glutaminolysis [220, 221]

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doi: 10.3390/ijms25031738 39 LiW

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Abdel-Gawad M, Ali-El-Dein B, Mehta S, Al-Kohlany KM, Elsobky E (2014) A correlation study between macro- and micro-analysis of pediatric urinary calculi

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