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The mouse research that established its mechanism and preclinical effects used subcutaneous injection at a fixed research dose (20 mg/kg, three times daily) a research-animal protocol, not a human administration guide

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[PMC free article: PMC3757949] [PubMed: 23142820] 159

Indeed, such analysis is affected by clustering of the points on the surface, which changes from dataset to dataset and is irrelevant for the overall dependence of Hb on B 12