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Additionally, the excessive metabolism of iron can accelerate this process, ultimately leading to ferroptosis in RPECs (169)

Hallett: Increased iron in the dentate nucleus of patients with Friedrich's ataxia

10.3389/fpls.2022.829118 13 FatimaN.El-WahabA.FawziM.AhmedaniE

The debilitating, slow damage created by high levels of blood sugar (glucose) destroys everything from your blood vessels to your eyes, kidneys, and nerves over time due to oxidative stress (remember the free radicals or reactive oxygen species (ROS)?)

Elevated intracellular amphetamine also activates trace amine-associated receptor 1 (TAAR1), leading to protein kinase A (PKA) and protein kinase C (PKC) signaling and phosphorylation of DAT, NET, and SERT (Step 3)