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A lower ratio generally indicates a more oxidized glutathione pool, but no universal reference interval applies across species, tissues, cells, or biofluids

Furthermore, a few patients who received iron supplements for iron deficiency experienced three times higher injury than untreated patients

In fact, the mean ventricular CSF concentration of vitamin E was 0.114 M after an increased monthly dosage (400, 800, 1,600, 3,200, and 4,000 IU/day) over 5 months [150], while its IC 50 (concentration at which a 50% inhibitory effect is observed) in a variety of in vitro radical scavenging assays was between 1.5 and 59 M [151]

This phenomenon is likely due to the anti-inflammatory effects of ferroptosis inhibitors, which target OC-STAMP through the inflammation-related RANKL pathway [30, 31], consequently decreasing the expression of OC-STAMP

We examined here the plausibility of the simplest hypothesis that the change of lipid composition and its resulting membrane properties are themselves sufficient to cause cell death (Fig

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