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Vitiello MV, Moe KE, Merriam GR, et al

[p130Cas]-tyrosine phosphate + H2O [p130Cas]-tyrosine + phosphate Substrates: dephosphorylation at Tyr165 Products: -

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NAD metabolism and mitochondria also provides a link to inflammaging, as low NAD+ levels or oxidized mitochondrial DNA induce activation of NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome, a sensor of the damageassociated molecular patterns (DAMPs) that accumulate with aging