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One of the major sources of propionyl-CoA in cells is the breakdown of the branched-chain amino acids (BCAAs) valine and isoleucine, which also accumulated in Alas1 KO adipocytes ( Figure 4a and Extended Data Figure 7a )

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Growth hormone plays a crucial role in metabolic regulation and body composition

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And beyond the enterocyte, glutamine also serves as a source of fuel for cells in the kidney, liver, brain neurons, immune cells, and the beta cells of the pancreas the cells that make insulin