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A 2024 pharmaceutical review in Pharmaceuticals raised tumorigenesis as a theoretical risk, though a 2025 response published in the same journal directly countered the concerns

and reappeared in a very lucrative scene that has widespread buy-in." The FDA previously warned against using unapproved GLP-1 drugs peptides designed for weight loss and other custom drugs, citing concerns that counterfeit products may lack the safety and quality standards that FDA-approved ones like Ozempic or Trulicity uphold

All data given in the figures apply to dilute aqueous solutions at ambient temperature

10.3390/ijms21228637 82 SedlakT

Chokkalla AK, Mehta SL, Kim T, Chelluboina B, Kim J, Vemuganti R

The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12