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Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine

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Incorporation of antioxidants such as coenzyme Q10 and resveratrol into cryopreservation media has been demonstrated in animal models to improve post thaw sperm quality, suggesting translational benefits for human fertility preservation [1]

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This compensatory mechanism is highly sensitive to changes in renal function, as even partial unilateral infarction, induced by ligation of one-half of the renal arteries, can be sufficient to increase IGF-1 expression in the contralateral kidney.19 Mechanistically, the upregulation of renal IGF-1 expression is stimulated by epidermal growth factor (EGF) in the renal collecting ducts, indicating a paracrine regulatory mechanism, as both, IGF-1 and EGF, are produced locally within the kidney.20 Moreover, the renal anabolic effects of IGF-1 are partly mediated through activation of the AKT-calcineurin-NFATc1 signaling pathway, which is involved in the regulation of vascular endothelial growth factor (VEGF).21,22 More recently, studies using single-cell RNA sequencing, have revelated that renal hypertrophy in mice activates sterol regulatory element-binding protein 2 (SREBP2) and increases cholesterol biosynthesis in medullary thick ascending limb cells