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The intra- and inter-assay coefficients of variation were kept below 10% for all assays, ensuring reliability and reproducibility of the results

however, at the same time temperature lowers the pKa of the acidic side chains in the C terminus thus facilitating the opposite effect of keeping fibrillation at bay

Vazquez, B

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Diabetic nephropathy, another major complication, involves progressive kidney damage that can lead to proteinuria, decreased glomerular filtration rate (GFR), and eventually end-stage renal disease [182]