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During chronic disease or injury, inflammatory cytokines (bad signals) flood the system, causing pain and further tissue destruction

Maghinay, Christina, and Mark Smith

(30,31) Both studies provided compelling evidence that semaglutide use is associated with reduced rates of prosthetic joint infections, sepsis, and hospital readmissions

Biomarkers of NRF2 signalling: current status and future challenges

Decreased stomach acid and inadequate chewing: an acidic environment is needed to free B12 from food, but low stomach acid and poor chewing are common as we age, and amongst those on long-term antacid and proton pump inhibitor (PPI) medication

This is due to the carbonate alkalinity equilibrium, but that's a conversation for another day