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Deficiency of Vitamin B12 greatly reduces the ability to make adrenalin from the precursors dopamine and nor-adrenalin Deficiency of Vitamin B12 greatly reduces the ability to make melatonin from the precursor serotonin Prolonged deficiency of vitamin B12 eventually results in over-production of dopamine and serotonin Over-production of dopamine and serotonin leads to receptor down-regulation and DEPRESSION and/or ANXIETY Subsequent correction of vitamin B12 depression leads to a rapid drop in dopamine and serotonin and a sudden production of adrenalin and melatonin Symptoms of adrenalin over-production are common Greater depression and/or anxiety can ensue Production of Adrenalin/epinephrine is critically dependent upon active methyl-Co(III)B12