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Rahil-Khazen et al., 2002)

10.1038/s41589-019-0330-6 178 PerluigiM.Fai PoonH.HensleyK.PierceW

There was also a significant increase in urine of m+3 orotate, which is derived from pyruvate carboxylation to oxaloacetate, demonstrating another mechanism by which Cse / mice can waste carbon in the absence of CoA (Extended Data Fig

Faassen Werenfridus Adrianus, Kemperman Gerardus Johannes, Ban Laarhoven, Johannes Hendrikus A

doi: 10.1016/j.bbrc.2007.08.041

However, a higher incidence of hemorrhage was observed in subjects with moderate hepatic impairment than in normal subjects [see Use in Specific Populations (8.7)]