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10.3389/fimmu.2015.00612 37 DeaneK

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940 TQCN treatment may improve numerous neurodegenerative diseases related with brain iron accumulation and ameliorate severe cognitive impairment in AD mice due to its multiplex modulation of the pathogenic process that triggers ferroptosis

Furthermore, gasdermins, which regulate inflammatory form of cell death, were upregulated in the brains of GCLC-KO mice, suggesting the contribution of pyroptosis to neuronal cell death in these animals

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