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Effectiveness and safety of treatments for degenerative ataxias: a systematic review

Cheng Y, Xu Q, Yu M, Dang C, Deng L, Chen H

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Crocetin is a naturally occurring dicarboxylic acid apocarotenoid that exhibits a chemopreventive effect on glioblastoma cells by inhibiting proliferation and inducing morphology changes that is mainly mediated through activation of neuronal markers (class III -tubulin and neurofilament) and suppression of mesenchymal markers (cluster of differentiation 44/90, octamer-binding transcription factor 3/4, and C-X-C chemokine receptor type 4) in glioma cells

Studies have suggested that MMPs degrade the vascular basement membrane components, resulting in disruption of the BBB (Xu et al., 2020)

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