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doi: 10.1016/j.fbio.2013.07.001 19

Although oxidative stress, ultraviolet radiation and metabolic dysfunction are welldocumented etiological factors, growing evidence implicates epigenetic dysregulation as a critical pathogenic mechanism in ARCs

MicroRNA antagonist therapy during normothermic machine perfusion of donor kidneys

This makes them important targets in cancer therapy and gives them significant potential in inducing senescence [81]

I dont see evidence of that either

Fasting decreases glycogen stores in the liver, and cells shift from carbohydrate to lipid and ketone metabolism, increasing BHB levels and blocking the NLRP3 inflammasome (Youm et al., 2015), which is implicated in age-related functional decline (Youm et al., 2013)