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Such targeted delivery systems are known to enhance the efficacy of drugs while reducing systemic side effects

This finding suggests that primary afferent hyperexcitability is a critical pathophysiological driver of pain, and we need to both understand its basis and develop therapeutics to target it

D., Cinelli, L

Peak Function vs

Nature 563 , 501507 (2018)

Conditions, such as diabetes or hyperglycemia, can lead to increased microglial reactivity, marked by upregulation of various molecules and pathways associated with glucose transport and sensing and inflammation and oxidative stress (Hsieh et al., 2019