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In addition to the previously mentioned immune senescence- and inflammation-related mechanisms, sarcopenia is also associated with oxidative stress in skeletal muscle

HO-1 can be expressed not only by stimulating its free heme substrate, but also by diverse pro-inflammatory stimuli

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McCoull W, Barton P, Broo A, Brown AJH, Clarke DS, Coope G, Davies RDM, Dossetter AG, Kelly EE, Knerr L, MacFaul P, Holmes JL, Martin N, Moore JE, Morgan D, Newton C, sterlund K, Robb GR, Rosevere E, Selmi N, Stokes S, Svensson TS, Ullah VBK, Williams EJ (2013) Identification of pyrazolo-pyrimidinones as GHS-R1a antagonists and inverse agonists for the treatment of obesity

The primary efficacy outcome in both the trials was to evaluate the pre- and post-treatment melanin indices

discussion 90S