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The inhibition of SIRT1 activity can induce cardiomyocyte apoptosis by increasing p53 acetylation and upregulating Bax expression

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Modi, P., Shah, B

Food and Drug Administration approved Keytruda (pembrolizumab) in combination with Alimta and cisplatin

Furthermore, it has been indicated that the antioxidant properties of leonurine may be attributable to its capacity to enhance SOD and CAT activity, whilst concomitantly reducing NAPDH oxidase 4 activity and malondialdehyde content 27,28,29

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