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Its sustained antidepressant effect is well established in the literature [21,22,23], but unfortunately its chronotropic changes following administration and the mechanisms involved have not been as extensively studied as with ketamine

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Example: 5 mg vial at 250 mcg per dose Total peptide: 5,000 mcg

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Animal data show that AF can cause renal vasoconstriction and decreased renal blood flow and even renal fibrosis or possibly renal micro-infarcts [40, 41]