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Spearman rank correlation coefficients were calculated between serum metabolite concentrations and clinical variables, including lipid profile, glycemic indices, and vascular parameters

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Noble CO, Krauze MT, Drummond DC, Forsayeth J, Hayes ME, Beyer J, Hadaczek P, Berger MS, Kirpotin DB, Bankiewicz KS, Park JW (2014) Pharmacokinetics, tumor accumulation and antitumor activity of nanoliposomal irinotecan following systemic treatment of intracranial tumors

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To address this, combining spatial metabolomics with single-cell transcriptomics is necessary to better understand metabolic changes at a cellular level