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The primary site of metabolism is in the liver by aromatic hydroxylation, N-dealkylation and deamination

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Potassium at the Origins of Life: Did Biology Emerge from Biotite in Micaceous Clay

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APP cleaves to form amyloid beta (A), while hyperphosphorylation leads to the separation and aggregation of Tau proteins from microtubules, creating tangles in nerve fibers of nerve cells