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Apoptosis can be initiated via two major pathways: the intrinsic (mitochondria-dependent) pathway, which is triggered by cellular stress and mitochondrial outer membrane permeabilization, and the extrinsic (death receptor-mediated) pathway, both of which converge on the activation of caspases to execute cell death [53]

Three small molecules (compounds 1, 2 and 3) previously identified to target Leishmania 16

In a placebo-controlled, crossover trial in a mixed population of Cannabis -experienced and Cannabis -nave subjects with MS with substantial spasticity, smoked Cannabis (4% delta-9-THC) on 3 occasions reduced the level of spasticity by ~50% compared with smoking placebo cigarette