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A sudden change in activity levels is the most common cause of Shin Splints

Current evidence suggests that FRDA pathogenesis creates a highly conducive environment for lipid peroxidation (Figure 1), driven by dysregulated iron handling, amino acid metabolic shifts, and the failure of both glutathione (GSH)-dependent and independent pathways [29,63]

The peptide chains fracture, destroying bioactivity entirely

Electroanalysis 26 , 12141223 (2014)

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