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Intestinal vitamin B12 level measurement Snap-frozen cecal and colonic digesta samples were weighed and homogenized with two rounds of beating (30 s at 4 m/s with a cooling step on ice) in a proprietary buffer provided by Calgary Laboratory Services: Diagnostic and Scientific Research Centre (Calgary, AB, Canada)

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Comment: One commenter recommended CMS consider a waiver process to exclude from Part D inflation rebate calculations a drug or biological that is essential to public health or that would cause economic hardship to the manufacturer, similar to the provisions included in the Prescription Drug User Fee Act

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