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The most common cause of non-traumatic lower limb amputation in most countries with high earnings, according to recent studies, is distal proximal neuropathy (DPN) (53)

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Low levels may suggest high demand due to illness, stress, or physical activity

Absolute contraindications are not established due to lack of clinical data

doi: 10.1016/j.jaci.2018.05.036 56 SmithPMHowittMRPanikovNMichaudMGalliniCABohlooly-YMet al