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A study with an endoplasmic reticulum-associated protein (RTN1, Reticulon-1) focused on the inhibition of histone deacetylase (HDAC) enzymes has shown that the protein exhibits inhibitory activity only in the form of a copper complex (Nepravishta et al., 2009[324])

Enzymatic characterization of recombinant rat DDHD2: a soluble diacylglycerol lipase

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Following HMGB1 inhibition or 5-HT7R knockout, the downstream Nrf2/xCT/GPX4 signaling pathways was upregulated, resulting in alleviated depressive-like behaviors (Du et al., 2025)

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The culture broth was subjected to liquidliquid extraction with EtOAc in a 1:2 ratio at room temperature, with stirring at 100 rpm for 72 h