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A general pattern of increasing consumption with increasing age (though often a slight drop after 55) held for most years between 1999 and 2020, although with some variation

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doi: 10.1080/15563650.2018.1540046 [PubMed] 31589567 de Oliveira AM, Paulino MV, Vieira APF, McKinney AM, da Rocha AJ, Dos Santos GT, Leite CDC, Godoy LFS, Lucato LT

Among them is a trial of e-cigarettes and heated tobacco products (which also produce less toxicants than cigarettes) versus medications like NRT in smokers who had previously failed to quit with traditional methods