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60 HP 95 DSIP Delta Sleep-Inducing Peptide ALIASES DSIP, delta sleep-inducing peptide, Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu CLASS Endogenous nonapeptide sleep / stress-pathway modulator FORMULA C35H48N10O15 SEQUENCE Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu HALF-LIFE Very short (minutes) plasma longer CNS retention reported ROUTES Subcutaneous (research) Intranasal (research) MECHANISM OF ACTION Nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) originally isolated from rabbit cerebral venous blood during electrically induced sleep states

CER induces BOK association with p-DRP1 at the MAMs The MAMs are enriched in glycosphingolipids and represent the microenvironment that enables mitochondrial fission 28

Studies have also shown that -HB increases oxidative phosphorylation via a Complex II-dependent mechanism

Lakshmanan et al

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[40] The incident was condemned by Miami Beach mayor Steven Meiner