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Some key areas where combination therapies may offer substantial benefits include: Cardiovascular Disease: Cellular senescence plays a key role in the development of cardiovascular diseases, particularly through the accumulation of senescent cells in blood vessels and the heart

16 ColletJ.-F.MessensJ

Furthermore, in the intention-to-treat analysis, the median relapse-free survival was 24.3 months (95% CI 18.634.6) for capecitabine and 17.4 months (95% CI 11.823.0) for surveillance, with an adjusted HR of 0.81 (95% CI 0.651.01)

doi: 10.3389/fncel.2022.1037641 Received 06 September 2022 Accepted 20 December 2022 Published 19 January 2023 Volume 16 - 2022 Edited by Daniel Reyes-Haro, Institute of Neurobiology, National Autonomous University of Mexico, Mexico Reviewed by Sergei Kirischuk, Johannes Gutenberg University Mainz, Germany