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Endothelial dysfunction is related to periodontitis, and pathogenic bacteria or products of PD can directly affect endothelial function ( Matrix Metalloproteinases (MMPs) Matrix metalloproteinases are found in the periodontium and are calcium-dependent zinc-containing proteolytic enzymes that are responsible for organ oogenesis, normal tissue turnover, and tissue breakdown (Nylund et al., 2015)

The most noticeable difference in whole-brain activity signatures between GLP-1MK-801 and semaglutide was the significantly higher number of cFOS + cells in the nucleus accumbens in response to GLP-1MK-801 compared with semaglutide and vehicle treatment

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