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however, this does not necessarily mean exercise can be replaced by MOTS-c supplementation

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doi: 10.1152/ajpheart.1996.270.4.H1149 177 BatemanRJBarthlemyNRHorieK

Since mtDNA, as discussed in the preceding article, lacks histone buffer proteins and lies in immediate proximity to the ROS-producing respiratory chain, it depends on external protective molecules