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These experiments provided a rationale for later mouse studies but did not establish a human fat-loss effect

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sulfonate e.g., trifluoromethanesulfonate, mesylate, tosylate, besylate, and the like halide e.g., fluor Another aspect of the invention pertains generally to the use of the cations of the invention to inhibit NNMT and diseases or conditions involving NNMT

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The alteration in the availability of both SAMe and PC has been shown in the etiology of fatty liver disease 3

Studies indicate that NNMT is closely related to inflammatory status