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J.de WetL

Physician , 80 (3), 265269

Indeed, primary GBM are essentially characterized by an amplification of EGFR (epidermal growth factor receptor) (36%), a deletion of p16InK4a (p16 cyclin-dependent kinase inhibitor 4a) (31%) and a mutated PTEN (phosphatase and tensin homolog) (25%)

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Insufficient energy production in the brain can result from mitochondrial damage, and migraine is a reaction to either an excess of oxidative stress or an inadequate amount of brain energy (Fila et al., 2019)