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Immunofluorescence revealed DDIT4 overexpression led to an accumulation of PGC-1 in the nucleus, where it exerted transcriptional activity (Fig

10.1080/10550490490436055 Summary Keywords methamphetamine, cocaine, synthetic cathinones, ketamine, nitrous oxide, heroin, nervous system damage Citation Wang J, Hao Y, Ma D, Feng L, Yang F, An P, Su X and Feng J (2025) Neurotoxicity mechanisms and clinical implications of six common recreational drugs

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Human data varies by use, so supervision matters