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School of Education & Human Sciences Joseph Higgins, Olathe, Kansas

The chemistry and biology of inhibitors and pro-drugs targeted to glutathione S-transferases

doi: 10.1016/j.phrs.2013.06.002

many of the studies are retrospective in nature, report small sample sizes, have not been validated in other studies, or have not been replicated in humans

Brain oxidative stress: Detection and mapping of anti-oxidant marker Glutathione in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy

NAC inhibits NF-B activation and upregulates nuclear factor erythroid 2-related factor 2 (Nrf2), promoting cellular antioxidant defences (Table 4) (Chen et al., 2025)