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The control group of test subjects had an incidence of spontaneous tumors of 30% with lung adenoma and breast tumors developed the most frequently with incidences of 20% and 8%, respectively [3]

In this study, we used MYCN -amplified HR-NB patient-derived xenografts (PDXs) and PDX-derived organoid models 12,24,25 to investigate multiple ferroptosis-inducing agents with different mechanisms of action

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