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Chemico-Biological Interactions , 111112 , 114

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When freeze-drying is performed without a protective matrix (such as sucrose or mannitol), residual bound water may cause collapse during the final drying stage

HIFs are vital at all key stages of metastatic dissemination, for example, processes such as local migration within the tumor and invasion of the surrounding stromal tissue by inducing an EMT-like process and remodeling the extracellular matrix [228]