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While the liver is the primary site of drug metabolism, it has recently been discovered that almost all oral drugs affect the gut microbiome (Vich Vila et al., 2020)

doi: 10.1016/j.immuni.2016.09.008 Summary Keywords trimethylamine N-oxide, coronary artery disease, diabetes mellitus, major adverse cardiovascular events, prospective cohort study Citation Yu X, Wang Y, Yang R, Wang Z, Wang X, Wang S, Zhang W, Dong J, Chen W, Ji F and Gao W (2024) Trimethylamine N-oxide predicts cardiovascular events in coronary artery disease patients with diabetes mellitus: a prospective cohort study

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4A indicate the concentration-dependent induction of IRE1, suggesting the involvement of ER stress activation in the autophagy-associated apoptosis in PFOS-treated RTCs

Haijes HA, Van Hasselt PM, Jans JJM, et al

Thiamine has an important role in mitochondria function and is essential for the function of several enzymes in mitochondria