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Wortel IMN, van der Meer LT, Kilberg MS, van Leeuwen FN (2017) Surviving stress: modulation of ATF4-mediated stress responses in normal and malignant cells

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Journal of Neuroscience Methods 203(1):41-49

This is largely due to a mismatch between its optimal window of interventionideally before or within one hour of disease onsetand real-world clinical scenarios

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In CKD, renal urate excretory mechanisms are compromised due to loss of renal function