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This is supported by the fact that the delivery of mRNA containing or m 5 C + purified from dsRNA and other contaminants using HPLC to dendritic cells did not trigger Type I IFN or TNF- expression, nor did it significantly induce genes associated with RNA sensor activation

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If some of these side effects are left untreated and become severe, serious health consequences can occur, including renal failure and even death

Prospective studies are warranted to vali- date this threshold and dene precise therapeutic targets