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Notably, mitochondrial autophagy downregulates mtROS levels by clearing damaged mitochondria, while deacetylases such as SIRT3 inhibit this pathway by enhancing antioxidant enzyme activity

While each indication demands rigorous evidence of safety and efficacy, existing clinical platforms show that intracranial biomaterials can be used safely when properly designed

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Phytomedicine 142, 156743

The symptoms are: Low energy Chronic fatigue Weakness Light-headedness Heart palpitations and shortness of breath Pale skin Dental problems, such as mouth sores and bleeding gums Sore red tongue Yellowing of the skin Mouth ulcers Constipation, diarrhoea, nausea, loss of appetite, or gas Nerve issues such as tingling or numbness, muscle weakness, and difficulty walking Joint pain Vision loss Mental illness, memory loss, or behavioural changes Poor concentration Dr Aravinda further noted that serious clinical symptoms like dementia, weariness, mood disruption, and megaloblastic anaemia can result from severe vitamin B12 insufficiency