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doi: 10.3389/fphar.2026.1808772 Received 11 February 2026 Revised 10 March 2026 Accepted 20 March 2026 Published 10 April 2026 Volume 17 - 2026 Edited by Amit Prasad, Indian Institute of Technology Mandi, India Reviewed by Wojciech Dabrowski, Medical University of Lublin, Poland Mustafa Can Guler, Atatrk University, Trkiye Updates Copyright 2026 Wang, Cai and Liang

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There is general agreement that M3 receptors are primarily responsible for the normal contraction of the urinary bladder , although M2 receptors are also present, and may act to oppose sympathetically mediated smooth muscle relaxation mediated by beta-3 receptors (Hedge, 2009