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GH peak/insulin-like growth factor-1 (IGF-1) were also significantly reduced in severe ME/CFS patients compared to controls and ME/CFS patients with mild disease

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Interestingly, we observed a transient rise in FOXC1 expression from day 0 to day 2, followed by downregulation by day 4 in all conditions

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It also oxidizes thiol groups of proteins, forming disulfide bonds that alter Bcl-2 family protein conformation and function, disrupting the balance between pro-apoptotic and anti-apoptotic proteins [79]