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Some cell types, among which the energy-ravenous and stress-sensitive brain neurons, cannot synthesize glutathione endogenously and rely on import from neighboring cells of the glia

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Consistent with this notion, metabolic imbalance-induced genomic instability and DNA damage may involve oxidative stress and DDR inefficiency

qRT-PCR analyses were performed using 2x qPCRBIO Sybr Green blue Mix (PCR Biosystem) on a Real-Time PCR Detection System (Applied Biosystems)

Recent Mendelian randomization findings further validate this framework: Dorea and Sellimonas appear protective, whereas Phascolarctobacterium and Ruminococcaceae UCG-004 are associated with increased PTSD risk (He et al., 2024)

(2013) Role of glutathione in cancer progression and chemoresistance